Nearly a decade after reports first surfaced linking the prescription pain reliever celecoxib (Celebrex) to an increased risk of heart attack, and two years after the American Heart Association (AHA) warned against the drug for people at risk of heart problems, about 11 million prescriptions for it are still filled each year, often for arthritis, menstrual cramps, and acute pain. Well, maybe it's no coincidence that Pfizer, maker of celecoxib, has resumed heavily advertising it directly to consumers, spending $54.8 million on ads in 2007 and $58.5 million in 2008. A new ad—a full two minutes long, and also available online at a man walking a dog and riding a bike. It suggests that the drug is no riskier than other related nonsteroidal anti-inflammatory drugs, such as ibuprofen (Advil and generic) and naproxen (Aleve and generic). While celecoxib may be appropriate for a small number of patients, our reservations about it remain strong. Although the evidence is mixed, some meta-analyses, which assess the combined data from many clinical trials, have linked celecoxib at higher or more frequent doses to an increased likelihood of heart attack compared with either a placebo or naproxen. Indeed, the government's Agency for Healthcare Research and Quality now says that naproxen is less likely than other NSAIDs to harm the heart. And the AHA says celecoxib should be used to treat people at risk of heart attack only if other measures have failed. That recommendation is based mainly on the ways that celecoxib acts in the body, which in theory may harm the heart more than other NSAIDs. An unfortunate effect of all NSAIDs is that they block production of an enzyme that normally protects the lining of the stomach from stomach acid. When he told the price to the ophthalmologist who had written him the prescription, "He said, 'Why don't you try to find a Canadian pharmacy that will sell it? '" recalled Bill, an 81-year-old retired statistician, who requested his real name not be published. Since then, he has regularly ordered the medication from Canadian outlets, which, after verifying his prescription, have the Copaxone shipped from the United Kingdom to him. A 28-week supply—one injectable vial per week—most recently cost him $1,200 from a Canadian pharmacy. The last time he checked prices of the same supply at U. pharmacies, he saw it would have cost him between $4,500 and $5,550, Bill said. Why Americans pay more for medicine Bill said he is happy with the thousands of dollars over the years that he's saved from buying from Canada, and with the effectiveness of the drug, which has kept his eye condition in check. But Bill's international online shopping violates the law—a fact that he was unaware of until he spoke with CNBC this week. It is illegal for individuals to import prescription drugs into the United States, with rare exceptions.
Celecoxib belongs to the group of medications called selective COX-2 inhibitors, which is a kind of nonsteroidal anti-inflammatory drug (NSAID). NSAIDs work by reducing a substance in the body that leads to inflammation (swelling) and pain. Celecoxib is used to treat the symptoms of osteoarthritis, ankylosing spondylitis, and rheumatoid arthritis in adults. It is also used to treat moderate-to-severe pain for a short-term period (less than 7 days), such as pain due to surgery, sprains, or tooth extractions. Celecoxib will only treat symptoms and decrease inflammation as long as you are taking the medication. It will not change the progress of the disease causing the pain and inflammation. This medication may be available under multiple brand names and/or in several different forms. To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more CELECOXIB (sell a KOX ib) is a non-steroidal anti-inflammatory drug (NSAID). This medicine is used to treat arthritis and ankylosing spondylitis. It may be also used for pain or painful monthly periods. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. They need to know if you have any of these conditions: -asthma -coronary artery bypass graft (CABG) surgery within the past 2 weeks -drink more than 3 alcohol-containing drinks a day -heart disease or circulation problems like heart failure or leg edema (fluid retention) -high blood pressure -kidney disease -liver disease -stomach bleeding or ulcers -an unusual or allergic reaction to celecoxib, sulfa drugs, aspirin, other NSAIDs, other medicines, foods, dyes, or preservatives -pregnant or trying to get pregnant -breast-feeding Take this medicine by mouth with a full glass of water. Take it with food if it upsets your stomach or if you take 400 mg at one time. Try to not lie down for at least 10 minutes after you take the medicine. Do not take more medicine than you are told to take.
Celebrex is a non-steroidal anti-inflammatory drug (NSAID) that is prescribed to relieve pain from arthritis and acute pain due to injury. Celebrex or Celecoxib generic is a newer form of NSAID called a selective COX-2 inhibitor. Most other NSAIDs also affect the COX-1 (cyclo-oxygenase) enzyme which can cause gastrointestinal problems. The generic alternative is not manufactured by the company that makes the brand product. If you experience the pain of osteoarthritis or rheumatoid arthritis, your doctor can provide a prescription to buy Celebrex or Celecoxib generic. Celebrex reduces the risk of stomach irritation while delivering relief from painful, swollen, inflamed joints by blocking the production of inflammation-causing chemicals in your body called prostaglandins. These chemicals are called into action by your immune system when there is an injury or threat to cause harm. Celebrex, a prescription pain medication in the same class as Vioxx, which was pulled from the market in 2004 over cardiovascular concerns, is as safe as over-the-counter (OTC) pain medications. However, you may want to think twice before switching from Advil or Aleve to Celebrex. The somewhat surprising finding is the result of a 10-year study conducted by Pfizer, the maker of Celebrex, involving more than 24,000 people with arthritis who either had heart disease or were at high risk for it. They were given either Celebrex (celecoxib), a drug known as a COX-2 inhibitor, Advil (ibuprofen) or Aleve (naproxen). The latter two are available OTC and are known as NSAIDs (non-steroidal anti-inflammatory drugs). Although the study was funded by Pfizer, the lead author was Steven Nissen, MD, a cardiologist at the Cleveland Clinic, who was one of the first physicians to sounds alarms about links between Vioxx and an increased risk of heart attack and stroke. Published in the New England Journal of Medicine, the study not only found that all 3 medications had similar efficacy, but all had nearly the same rate of heart disease, heart attack or stroke from taking it.
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