I have been on Tamoxifen for 1 year now following 4 chemo treatments and radiation for a ER positvie tumor. visit revealed elevated liver function test and I have been experiencing some abdominal pain. I have had a cat scan of the abdomen which was read as negative for mets but showed fatty liver disease. In researching, I found tamoxifen listed as one of the causes. Just wondering if anyone has had this problem or is aware of anyone who has. I am on Arimdex and have recently had a pelvic CT that showed fatty liver. On blood work some of y liver enzymes are up as well. Spoke with oncologist he spoke with clinical pharmacist and they say Arimidex doesn't cause this???? I do need to loose weight, which is another cause of fatty liver, so am going to weight watchers now. Diane E wrote: I had labs drawn yesterday for my onc check up. Previous labs done were in December and they were fine. My AST and ALT are now elevated at 83 and 76, up from 36 and 32 in December. I see the onc today but already had a heads up from the Nurse Practioner that he is going to recheck them in a week and see what happens before doing a liver ultrasound. I hope it is the tamoxifen, but that really cuts down on years of meds available for ER and the ovaries would need to come out. I guess it is a small price to pay if he can tell me I am still NED. I did have a PET/CT in December that was negative and he told the NP he took great comfort in having that info. Diane Apr 30, 2009 PM jpann39 wrote: Diane I was told from the get go that Tamox is known to raise those #'s..... Well, I had inflammatory breast ca, so I have to get past the fact that 4 months is plenty of time for everything to rear its ugly head. I just did a 12 hr fasting blood draw and will see my doctor this coming week so will see what it has done to my numbers as Ive been on it over 2 years and had slightly high cholestrol to begin with. Best wishes Jule Apr 30, 2009 PM desdemona222b wrote: I had the same problem, but my liver enzymes were much higher than that - more like around 156 or something.
My sister in low has a early stage breast cancer and is taking tamoxifen pills. I was doing some research on the net and found out that tamoxifen can cause liver cancer. What is the connection between tamoxifen and liver cancer ? It is not known Tamoxifen to cause liver cancer in humans. I would be careful while on Tamoxifen and make sure to have tests done to monitor how this drug is affecting your body. Sometimes it can cause other liver toxicities in patients, which can be severe or life threatening. Another women I know who took Tamoxifen also for 5 years, had to have a hysterectomy due to suspicious changes in her uterus. Blood tests are usually performed from time to time to check liver function. I think there needs to be more research on this drug. I'm sure your sister in low will find Tamoxifen beneficial. My mother took part in a tamoxifen trial in the UK. There are clinical evidences, about tamoxifen used as adjuvant therapy for early stage breast cancer, that showed reduced risk of recurrence of the original cancer and also reduced risk of developing new cancers in the other breast. My mother was taking Tamoxifen for 5 years after having breast cancer. She had had a very early stages lump removed from one breast with an excellent prognosis as it was such early stages. Anyway, she agreed to take part in a 5 year tamoxifen trial. Your order will be packed safe and secure and dispatched within 24 hours. This is exactly how your parcel will look like (pictures of a real shipping item). It has a size and a look of a regular private letter (9.4x4.3x0.3 inches or 24x11x0.7cm) and it does not disclose its contents I prefer not to take generics of Nolvadex if I can buy the original Nolvadex online from the certified company. The seller cares about its name and image and makes a quick delivery. As for me, I also prefer the original rather than analogues of the same drug. The principles of effectiveness are different, and there might be more side effects. I take Nolvadex only online, as I already trust the company, and they deliver it without any problems. I was afraid of side effects of Nolvadex, but, actually, I didn’t face them at all. I’ve been taking Nolvadex for a few months, and it has a good effect on me.
Liver Cancer and Liver Disease Tamoxifen is toxic to the liver, and there have been reports of acute hepatitis in patients treated with tamoxifen. Liver damage has occurred in every animal given tamoxifen. Full text Full text is available as a scanned copy of the original print version. Get a printable copy PDF file of the complete article 220K, or click.