Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product Concentrate, Oral: Zoloft: 20 mg/m L (60 m L [DSC]) [contains alcohol, usp, menthol]Generic: 20 mg/m L (60 m L)Tablet, Oral: Zoloft: 25 mg [scored; contains fd&c blue #1 aluminum lake, fd&c red #40 aluminum lake, fd&c yellow #10 aluminum lake, polysorbate 80]Zoloft: 50 mg [scored; contains fd&c blue #2 aluminum lake]Zoloft: 100 mg [scored; contains polysorbate 80]Generic: 25 mg, 50 mg, 100 mg Antidepressant with selective inhibitory effects on presynaptic serotonin (5-HT) reuptake and only very weak effects on norepinephrine and dopamine neuronal uptake. In vitro studies demonstrate no significant affinity for adrenergic, cholinergic, GABA, dopaminergic, histaminergic, serotonergic, or benzodiazepine receptors. Hepatic; may involve CYP2C19 and CYP2D6; extensive first pass metabolism; forms metabolite N-desmethylsertraline (APA [Gelenberg 2010]); Note: Children 6 to 17 years may metabolize sertraline slightly better than adults, as pediatric AUCs and peak concentrations were 22% lower than adults when adjusted for weight; however, lower doses are recommended for younger pediatric patients to avoid excessive drug levels) Urine (40% to 45% as metabolites); feces (40% to 45%; 12% to 14% as unchanged drug) Depression: The onset of action is within a week, however, individual response varies greatly and full response may not be seen until 8 to 12 weeks after initiation of treatment (APA [Gelenberg 2010]). Plasma: Sertraline: 4.5 to 8.4 hours Sertraline: Mean: 26 hours; N-desmethylsertraline: 62 to 104 hours Children 6 to 12 years: Mean: 26.2 hours (Alderman 1998)Children 13 to 17 years: Mean: 27.8 hours (Alderman 1998)Adults 18 to 45 years: Mean: 27.2 hours (Alderman 1998) 98% Sertraline clearance was reduced in patients with chronic mild liver impairment resulting in a 3-fold greater exposure. Plasma clearance 40% lower; steady state achieved after 2 to 3 weeks Children 6 to 17 years may metabolize sertraline slightly better than adults, as pediatric AUCs and peak concentrations were 22% lower than adults when adjusted for weight; however, lower doses are recommended for younger pediatric patients to avoid excessive drug levels) Major depressive disorder (unipolar): Treatment of unipolar major depressive disorder (MDD) in adults. Obsessive-compulsive disorder: Treatment of obsessions and compulsions in patients with obsessive-compulsive disorder (OCD). Zoloft (Sertraline) is a selective-serotonin reuptake inhibitor (SSRI) prescribed for a variety of medical conditions, including: major depressive disorder, obsessive-compulsive disorder, panic disorder, and social anxiety disorder. On occasion, Zoloft is even used off-label to help manage symptoms of premenstrual syndrome (PMS), body dysmorphic disorder, vascular headaches, and premature ejaculation. Though the effectiveness of Zoloft is generally regarded as analogous to other antidepressant medications, one meta-analysis published in The Lancet (2009) reported that Zoloft may be superior to a majority of serotonergic antidepressants in terms of efficacy and tolerability among adults with major depressive disorder. Because Zoloft is an effective treatment option for numerous conditions, and is sold for a low cost due to its generic status (approximately $1.50 for a monthly prescription) – it remains a popular medication. In the event that you’ve been prescribed Zoloft to treat a medical condition, you might be wondering how long it’ll take for the medication to work or fully “kick in.” In fact, you’ve probably been Googling how long it took for Zoloft to start working and are finding all sorts of mixed reviews: some suggesting that it works rapidly (immediately) and others noting that it takes weeks to reach full effect. Although Zoloft starts working immediately in terms of exerting a neurophysiologic effect, it may take weeks for the medication to facilitate a desired or clinically relevant therapeutic effect. That said, some users may notice that the medication starts working in a short amount of time (e.g. within hours or days of initiating treatment), whereas others may report that the medication takes several weeks to start working. Does the medication work right away – or will you need to take it for 4 to 6 weeks to derive therapeutic benefit?
Diarrhea is an increase in the frequency of bowel movements or a decrease in the form of stool greater looseness of stool. Although changes in frequency of bowel movements and looseness of stools can vary independently of each other, changes often occur in both. Learning Objectives. This is a beginning level course. After completing this course, mental health professionals will be able to Discuss ethical and legal considerations in providing information about medications to clients.