Hello everyone, I am 39 year old female just diagnosed recently with Addisons disease after 8 months of vomiting and feeling terrible. I have been put on 20 mg of hydrocortisone in the am and 10mg at night. However, the 20mg didn't seem to be enough and I increased the dose gaining about 13 pounds in a month and the salt cravings are severe. My endo has now changed my med's to 5mg prednisone in the am and 2.5 at night w/.1mg of floronef. However, I have a couple of concerns 1 of course is weight gain but I'm also concerned about the long term use of Prednisone. Has anyone had any experience with hydrocortisone Vs. and has anyone successfully controlled the weight gain and how? Thanks Justine Justine, Were you actually diagnosed with addisons? I "much" prefer it, but try to stick with HC because it is like what a normal body would produce & does not process through the liver. This table takes no account of mineralocorticoid effects, nor does it take account of variations in duration of action Prednisolone 5mgis equivalent to betamethasone 750 mcgis equivalent to cortisone acetate 25 mgis equivalent to dexamethasone 750 mcgis equivalent to deflazacort 6mgis equivalent to hydrocortisone 20mgis equivalent to methylprednisolone 4mgis equivalent to traimacinolone 4mg Note that mineralocorticoid side effects are most marked with fludrocortisone, but are significant with cortisone, hydrocortisone, corticotropin, and tetracosactide (tetracosacrtin). Minerlacorticoid actions are negligible with the high potency glucocorticoids, betamethasone and dexamethasone, and occur only slightly with methylprednisolone, prednisolone, triamcinolone. Topical corticosteroids: The potency of topical corticosteroids is determined by The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions Ltd® receives funding from advertising but maintains editorial independence. GPnotebook stores small data files on your computer called cookies so that we can recognise you and provide you with the best service. If you do not want to receive cookies please do not use GPnotebook.
Hydrocortisone oral will decrease the level or effect of prednisone oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Disclaimer The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care. Hydrocortisone has not caused severe Cushings like the Prednisone did, but we've also been working with much lower doses. My memory is a little foggy, but I seem to recall starting at 20mg of Prednisone last time and camping there for months, which is a lot.