Free Movies UK is a non-profit organisation dedicated to getting its members as many free cinema tickets as possible. For over 7 years, our community has helped people from all round the UK get tickets from screening organisers such as Showfilmfirst, Ourscreen, Sky Rewards and Times , and also through competitions. Being a community based on helping each other out, you'll find that free films are just the tip of a lovely, warm iceberg. Methylprednisolone is used to treat conditions such as arthritis, blood disorders, severe allergic reactions, certain cancers, eye conditions, skin/kidney/intestinal/lung diseases, and immune system disorders. It decreases your immune system's response to various diseases to reduce symptoms such as swelling, pain, and allergic-type reactions. Methylprednisolone may also be used with other medications in hormone disorders. Take this medication by mouth as directed by your doctor, usually with food or milk. The dosage and length of treatment are based on your medical condition and response to treatment. Different dosing schedules exist for this medication. If you are not taking the same dose each day or if you take this medication every other day, it may help to mark your calendar with a reminder. Consult your doctor or pharmacist if you have any questions. Do not increase your dose or use this drug more often or for longer than prescribed.
Day 1: 8 mg PO before breakfast, 4 mg after lunch and after dinner, and 8 mg at bedtime Day 2: 4 mg PO before breakfast, after lunch, and after dinner and 8 mg at bedtime Day 3: 4 mg PO before breakfast, after lunch, after dinner, and at bedtime Day 4: 4 mg PO before breakfast, after lunch, and at bedtime Day 5: 4 mg PO before breakfast and at bedtime Day 6: 4 mg PO before breakfast May be tapered over 12 days (to decrease chance of dermatitis flareup) Methylprednisolone: Usual dosing range, 2-60 mg/day PO divided q6-24hr Methylprednisolone acetate: Usual dosing range, 10-80 mg IM every 1-2 weeks; as temporary substitute for PO, given in daily IM dose equal to daily PO dose; for prolonged effect, given in weekly IM dose equal to 7 times daily PO dose; unlike methylprednisolone sodium succinate, may not be given IV Methylprednisolone sodium succinate: Usual dosing range, 10-250 mg IM/IV up to q4hr PRN Acne Adrenal suppression Amenorrhea Delayed wound healing Delirium Diabetes mellitus Edema Emotional instability Erythema Fluid retention GI perforation Glucose intolerance Growth suppression (children) Hallucinations Headache Hepatomegaly Hepatitis Hypokalemic alkalosis Increased transaminases Insomnia Leukocytosis Menstrual irregularity Myopathy Neuritis Osteoporosis Peptic ulcer Perianal pruritus Pituitary adrenal axis suppression Protein catabolism Pseudotumor cerebri (on withdrawal) Psychosis Sodium and water retention Seizure Tachycardia Ulcerative esophagitis Urticaria Vasculitis Vertigo Weight gain Untreated serious infections Documented hypersensitivity to drug or components (eg, lactose monohydrate from cow milk) Intrathecal administration Systemic fungal infection (except intra-articular injection in localized joint conditions) IM route is contraindicated in idiopathic thrombocytopenic purpura Premature infants (formulations containing benzyl alcohol only) Traumatic brain injury (high doses) Administration of live or live, attenuated vaccines is contraindicated in patients receiving immunosuppressive doses of corticosteroids Use with caution in cirrhosis, ocular herpes simplex, hypertension, diverticulitis, hypothyroidism, myasthenia gravis, peptic ulcer disease, osteoporosis, ulcerative colitis, psychotic tendencies, renal insufficiency, pregnancy, diabetes mellitus, history of seizure disorders, multiple sclerosis, thromboembolic disorders, myocardial infarction Long-term treatment: Risk of osteoporosis, myopathy, delayed wound healing Minimal mineralocorticoid activity Use in septic shock or sepsis syndrome not proven effective and may increase mortality in some patients including patients with elevated serum creatinine and patients who develop secondary infections Clearance of corticosteroids may increase in hyperthyroid patients and decrease in hypothyroid ones; dose adjustments may be necessary Patients receiving corticosteroids should avoid chickenpox or measles-infected persons if unvaccinated Latent tuberculosis may be reactivated (patients with positive tuberculin test should be monitored) Some suggestion (not fully substantiated) of slightly increased cleft palate risk if corticosteroids are used in pregnancy May cause hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing syndrome, or hyperglycemia Prolonged corticosteroid use may result in elevated IOP, glaucoma, or cataracts Killed or inactivated vaccines may be administered; however, the response to such vaccines cannot be predicted Immunization procedures may be undertaken in patients who are receiving corticosteroids as replacement therapy in physiologic doses (eg, for Addison’s disease) Injection may result in dermal and/or subdermal changes forming depressions in the skin at injection site; to minimize incidence of dermal and subdermal atrophy, care must be exercised not to exceed recommended doses in injections; avoid injection into deltoid muscle due to high incidence of subcutaneous atrophy Increased dosage of rapidly acting corticosteroids indicated in patients on corticosteroid therapy subjected to any unusual stress before, during, and after the stressful situation Not for use in the treatment of traumatic brain injury Average and large doses of corticosteroids can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium; dietary salt restriction and potassium supplementation may be necessary; all corticosteroids increase calcium excretion Drug induced secondary adrenocortical insufficiency may be minimized by gradual reduction of dosage; relative insufficiency may persist for months after discontinuation of therapy; therefore, in situation of stress occurring during that period, hormone therapy should be reinstituted Rarely, high doses of cyclically pulsed intravenous methylprednisolone (usually for the treatment of exacerbations of multiple sclerosis at doses of 1 g/day) can induce a toxic form of acute hepatitis; discontinue therapy if it occurs; since recurrence has occurred after re-challenge, avoid use in patients with a history of toxic hepatitis caused by methylprednisolone With increasing doses of corticosteroids, the rate of occurrence of infectious complications increases; corticosteroids may also mask some signs of current infection; corticosteroids may exacerbate systemic fungal infections and should not be used in presence of such infections unless needed to control drug reactions; latent amebiasis or active amebiasis should be ruled out before initiating corticosteroid therapy patients who have spent time in tropics or patients with unexplained diarrhea Lowest possible dose should be used to control condition under treatment; when reduction in dosage possible, reduction should be gradual Risk/benefit decision must be made in each individual case as to dose and duration of treatment and as to whether daily or intermittent therapy should be used Kaposi’s sarcoma reported in patients receiving corticosteroid therapy, most often for chronic conditions; discontinuation of therapy may result in clinical improvement Although controlled clinical trials have shown corticosteroids to be effective in speeding the resolution of acute exacerbations of multiple sclerosis, they do not affect the ultimate outcome or natural history of the disease Psychic derangements may appear when corticosteroids used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression, to frank psychotic manifestations; also, existing emotional instability or psychotic tendencies may be aggravated by corticosteroids Give consideration to potential for hypersensitivity reactions to cow’s milk ingredients in Solumedrol; if appropriate, stop administration of injection solution Solumedrol and treat patient’s condition accordingly; alternative treatments, including use of corticosteroid formulations that do not contain ingredients produced from cow’s milk, should be considered for acute allergy management Increased incidence of scleroderma reported in patients with systemic sclerosis; use caution Potent glucocorticoid with minimal to no mineralocorticoid activity Modulates carbohydrate, protein, and lipid metabolism and maintenance of fluid and electrolyte homeostasis Controls or prevents inflammation by controlling rate of protein synthesis, suppressing migration of polymorphonuclear leukocytes (PMNs) and fibroblasts, reversing capillary permeability, and stabilizing lysosomes at cellular level Solution: D5/0.5 NS, D5/NS, D5W, LR, NS Additive: Chloramphenicol sodium succinate, cimetidine, clindamycin, dopamine, granisetron, heparin, norepinephrine, penicillin G potassium, ranitidine, theophylline, verapamil Syringe: Diatrizoate meglumine, diatrizoate meglumin/diatrizoate sodium, granisetron, iohexol, iopamidol, iothalamate meglumine, ioxalate meglumine/ioxalate sodium, metoclopramide Y-site (partial list): Acyclovir, amifostine, amiodarone, cisplatin, dopamine, enalaprilat, famotidine, heparin, inamrinone, linezolid, meperidine, metronidazole, midazolam, morphine, sodium bicarbonate Additive: Aminophylline(? ), glycopyrrolate, metaraminol, nafcillin, penicillin G sodium Syringe: Doxapram Y-site: Allopurinol, amsacrine, ciprofloxacin, cisatracurium(? ), etoposide phosphate, fenoldopam, filgrastim, gemcitabine, heparin/hydrocortisone(? ), propofol, sargramostim, vinorelbine, vitamins B and C(? ) Inject directly into vein or into tubing of running IV Injection: Administer over at least 1 minute Infusion: Further dilute reconstituted mixture with D5W, NS, D5/NS, or other compatible solution Push: Administer over 10-20 minutes The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Prednisone is a corticosteroid (steroid), but different from anabolic steroids. Corticosteroids, unlike steroids, are not used by bodybuilders and athletes to build muscle. Prednisone is widely used in the treatment of many other conditions, including multiple sclerosis, asthma, ulcerative colitis, skin diseases, lupus and severe allergies. Prednisone is also for dogs and cats as a corticosteroid used to treat inflammatory arthritis and boost the immune system. There are two types of corticosteroids: mineralocorticoids and glucocorticoids. Prednisone is a glucocorticoid, a medication known for its impressive anti-allergic and anti-inflammatory effects. As a rule, in the case of stress and inflammation, the human body and the adrenal glands produce cortisone, which combats inflammation in the body.
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